Rybelsus Prices, Coupons, and Savings Tips Taken once daily, Rybelsus is FDA-approved to manage blood sugar in conjunction with diet and exercise in individuals with type 2 diabetes. Rybelsus is an innovative oral medication that manages blood sugar levels in individuals with type 2 diabetes. Its main ingredient – semaglutide – acts as a glucagon-like peptide-1 (GLP-1) receptor agonist, stimulating the release of insulin and reducing glucagon secretion. This process ultimately leads to improved blood …